[Event Report] 11th Keio-Stanford Webinar (held on November 19, 2022)

11th Keio-Stanford Webinar

The 11th Keio-Stanford Webinar was held on Saturday, November 19, 2022. The theme for this webinar was the "Evolution of CRISPR/Cas Technology." The Department of Anesthesiology, Perioperative and Pain Medicine (SLDDDRS) at Stanford School of Medicine; and the Department of Physiology at the School of Medicine and Yagami Data Security Lab at Keio University, acted as hosts, while KGRI; the Life Science Innovation Network Japan (LINK-J); and the Japan Science and Technology Agency (JST) served as co-hosts. Approximately 100 people participated in the webinar.

To begin Professor Ronald G. Pearl (Chairman, SLDDDRS Stanford) and Professor Hideyuki Okano (Keio University School of Medicine; Head of International Advisory Board of SLDDDRS) delivered opening remarks for the event, explaining the significance of the Keio-Stanford Webinar and sharing the latest findings and technology in genome editing using CRISPR/Cas systems in line with the day's theme.

Four speakers gave presentations during the event:

  1. In the first Keynote Presentation, Professor Le Cong from Stanford University spoke on a new technology combining microbial single-strand annealing proteins (SSAPs) with catalytically inactive dCas9, which promotes the knock-in of long kilobase-scale sequences in mammalian cells. This technology applies to various cell types, including human stem cells, and can provide opportunities for safer long-sequence genome editing.

  2. For the second Keynote Presentation, Dr. Hiroki Sasaguri from RIKEN discussed the base editing technology, which can target single nucleotides. He generated Alzheimer's disease model mice by using this technology. This research also shows promise in applications for other neurodegenerative diseases.

  3. In Short Talk 1, Dr. Makoto Saito from the Broad Institute of MIT and Harvard introduced the CRISPR-associated transposase (CAST) system found in prokaryotic cells and how this system can be applied to mammalian cells.

  4. In Short Talk 2, Akisa Nemoto, a PhD student at the Keio University School of Medicine, presented the epigenome editing. She applied this technology to repair imprinting abnormalities of Prader-Willi Syndrome (PWS).

A Q&A session was also held during the event. Panelists and audience alike showed great enthusiasm for the topics. Professor Hideyuki Okano and Professor Peter Kao (Stanford University School of Medicine, SLDDDRS) delivered their closing remarks and gave an overall summary of the webinar.

[Event information]
11th Keio-Stanford Webinar (November 19, 2022)

[Event report]
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