[Event Report] 12th Keio-Stanford Webinar (held on January 14, 2023)

12th Keio-Stanford Webinar

The 12th Keio-Stanford Webinar was held on Saturday, January 14, 2023. The theme for this webinar was "Stem Cells and Development of Model Animals" The Department of Anesthesiology, Perioperative and Pain Medicine (SLDDDRS) at Stanford School of Medicine; and the Department of Physiology at the School of Medicine and Yagami Data Security Lab at Keio University, acted as hosts, while KGRI; the Life Science Innovation Network Japan (LINK-J); and the Japan Science and Technology Agency (JST) served as co-hosts. Approximately 100 participants attended the webinar.

To begin, Professor Ronald G. Pearl (Chairman, SLDDDRS Stanford) and Professor Hideyuki Okano (Keio University School of Medicine; Head of International Advisory Board of SLDDDRS) delivered opening remarks for the event, explaining the significance of the Keio-Stanford Webinar and summarizing the latest findings and technology related to tissue homeostasis and senescence using various experimental animal models (the Drosophila fly, naked mole-rat, and jellyfish) in line with the day's theme.

The event then continued with lectures from three speakers:

  1. In Keynote Lecture 1, Associate Professor Lucy Erin O'Brien from Stanford University presented a model using the Drosophila fly gut. She introduced a model of tissue homeostasis in the Drosophila gut maintained through its regulation of cell growth and shrinkage. She demonstrated the molecular mechanism of the effect of dying gut cells on neighboring cells.

  2. In Keynote Lecture 2, Associate Professor Kyoko Miura from Kumamoto University introduced the discovery of a resistance to chemical carcinogenesis induction given through a dampened inflammatory response in the longest-living rodent, the naked mole-rat (NMR), as well as its inability to induce necroptosis as part of its molecular cancer resistance mechanism. She further discussed the senescence-induced cell death specific to NMR and its molecular mechanism.

  3. In the Short Talk, Lecturer Yuichiro Nakajima from the Graduate School of Pharmaceutical Sciences at The University of Tokyo introduced the research using the cnidarian jellyfish Cladonema pacificum. Touching upon the phenomenon in which blastema cells in the regenerating jellyfish tentacle are supplied with repair-specific proliferative cells, he discussed the similarity of tentacle regeneration to appendage regeneration in certain vertebrates and the possibility of convergent evolution of the blastema-supplying mechanisms.

A Q&A session was also held during the event. Panelists and audience alike showed great enthusiasm for the topics. Professor Hideyuki Okano and Professor Peter Kao (Stanford University School of Medicine, SLDDDRS) delivered the closing remarks and summarized the webinar.

[Event information]
12th Keio-Stanford Webinar (January 14, 2023)

[Event report]
1st Keio-Stanford Webinar "Neurodegenerative diseases" (held on January 30, 2021)
2nd Keio-Stanford Webinar "Organoids" (held on March 20, 2021)
3rd Keio-Stanford Webinar "Regenerative medicine" (held on May 29, 2021)
4th Keio-Stanford Webinar "Sleep" (held on July 17, 2021)
5th Keio-Stanford Webinar "Transdifferentiation by Manipulating Transcriptional Factors" (held on October 16, 2021)
6th Keio-Stanford Webinar "Frontiers of molecular cell biology and its implementation in society" (held on November 6, 2021)
7th Keio-Stanford Webinar "Advanced BioScience Webinar for Drug, Device Development" (held on January 22, 2022)
8th Keio-Stanford Webinar "Current Topics in Neuroscience" (held on March 26, 2022)
9th Keio-Stanford Webinar "Pattern Formation and Stem Cell Development" (held on July 23, 2022)
10th Keio-Stanford Webinar "Functional Genomics" (held on October 1, 2022)
11th Keio-Stanford Webinar "Evolution of CRISPR/Cas Technology" (held on November 19, 2022)