KGRI Lecture Series: (Aug.3, 2018) #2"Implantable microdevices for healthcare"


The Keio University Global Research Institute (KGRI) aims to promote international research and educational exchange and invites those working in the forefront of research and education in Japan and overseas to give lectures.

On this occasion, Prof. Yun Jung Heo (Assistant Professor) from the Department of Mechanical Engineering, Kyung Hee University in Republic of Korea will give a lecture titled "Three-dimensional microfabrication using multidirectional photolithography".

Date & time: Friday, August 3, 16:30-18:20 (Open 16:00)
16:30-17:25 Lecture#1 Prof. Filippo Rossi
17:25-18:20 Lecture#2 Prof. Yun Jung Heo
Venue: 16th Building-A 3F Meeting Room, Yagami Campus, Keio University
Host: Keio University Global Research Institute's Creativity Initiative (Core Project)
Language: English (No simultaneous interpretation provided)
Open to anyone. No admission fee, Pre-registration not required

Summary of lecture:

1. Subcutaneous sensors for continuous glucose monitoring
Continuous glucose monitoring system (CGMS) with implanted sensors allows diabetic patients to effortlessly recognize changes in blood glucose concentration and signals a warning in the case of high and low blood glucose concentrations, even when diabetic patients are sleeping. We developed fluorescent hydrogel fibers and implanted sensors under mouse ear skin. Fluorescence intensity of implanted hydrogel fibers continuously responded to blood glucose concentrations for up to 140 days, thus showing potential for subcutaneous sensors for long-term CGMS.
2. Photolithography for microneedle fabrication
Microneedles have been explored as a new class of effective transdermal drug delivery systems (DDS) with a minimally invasive, less painful and self-administrable method. We proposed inclined/rotated photolithography for direct fabrication of negative-photoresist and photocurable-hydrogel microneedles. We estimated microneedle dimensions based on theoretical analysis and demonstrated the scalability of inclined/rotated UV lithography. This estimable scalability can be powerful in on-demand microneedle fabrication for wide applications.

Biography :
Yun Jung Heo is an Assistant Professor of the Department of Mechanical Engineering at Kyung Hee University, Republic of Korea. Yun Jung Heo received her B.S. and M.S. degrees in the Department of Mechanical Engineering and BioSystems from Korea Advanced Institute of Science and Technology (KAIST) in 2004 and 2006. She began her postdoctoral work with Prof. Takeuchi at the University of Tokyo in 2009 after receiving her Ph.D. in Mechano-Informatics from the University of Tokyo. Then, she moved to Tokyo University of Agriculture and Technology as an Associate Professor in 2013. Since 2016, she has started her laboratory at Kyung Hee University and been focusing on designing implantable microdevices for continuous health monitoring and disease treatment.

Poster #2

Department of Mechanical Engineering, Faculty of Science and Technology
Hiroaki Onoe (E-mail: onoe[at]mech.keio.ac.jp)
(Please replace "[at]" with "@".)