KGRI Lecture Series: (Apr.20, 2018) "Enabling technology platforms in vitro for biological applications"


The Keio University Global Research Institute (KGRI) aims to promote international research and educational exchange and invites those working in the forefront of research and education in Japan and overseas to give lectures.
On this occasion, Dr. Nakwon Choi from Korea Institute of Science and Technology (KIST) in Korea will give a lecture titled "Enabling technology platforms in vitro for biological applications ".

Date & time: Friday, April 20, 17:00-18:30 (Open 16:45)
Venue: 16th Building-A 3F Meeting Room, Yagami Campus, Keio University
Host: Keio University Global Research Institute's Creativity Initiative
Language: English (No simultaneous interpretation provided)
Open to anyone. No admission fee, Pre-registration not required

Summary of lecture:
Part 1: Brain/neural tissue engineering In native tissues, cellular and acellular components are anisotropically organized and often aligned in specific directions, providing structural and mechanical properties for actuating biological functions. Thus, engineering alignment not only allows for emulation of native tissue structures but might also enable implementation of specific functionalities. By exploiting the elastomeric property of polydimethylsiloxane and fibrillogenesis kinetics of collagen, here we introduce a simple yet effective method to assemble and align fibrous structures in a multi- modular three-dimensional conglomerate. Applying this method, we have reconstructed the CA3-CA1 hippocampal neural circuit three-dimensionally in a monolithic gel.

Part 2: Hydrogel-based multiplex bioassay Photocrosslinkable hydrogel such as polyethylene glycol diacrylate (PEGDA) is an appealing matrix for detecting various biological markers such as DNAs, miRNAs, mRNAs, and protein. We present hydrogel-based multiplex bioassays enabled by photopatterning PEGDA constructs in microfluidic channels. This platform can serve as a useful tool for both in vitro diagnostics and prognosis.

Biography :
Nakwon Choi is Principal Research Scientist at Center for BioMicrosystems, Brain Science Institute, KIST. He received his B.S. in Chemical Engineering from Seoul National University in 2004, and later M.S. and Ph.D. in Chemical Engineering from Cornell University in 2008 and 2010. He continued at Cornell University as a postdoctocal associate. Then, he moved to Novartis Institutes for Biomedical Research (NIBR) and Massachusetts Institute of Technology (MIT) as a Presidential Postdoctoral Fellow. Since 2012, he has started his laboratory at KIST and been focusing on developing enabling technology platforms for various biological applications, primarily including brain/neuroscience.


Hiroaki Onoe (E-mail: onoe@mech.keio.ac.jp)