The regulation of aging and aging associated diseases through "Optimal Nutrition"
Longevity
Summary
Metabolites and hormones induced by diet regulate gene expression and tissue function during aging. Calorie restriction is a well known intervention to extend lifespan and its downstream molecules such as sirtuins, mTOR and FOXO have a crucial role in the prevention of aging associated diseases including Alzheimer's disease, sarcopenia, type 2 diabetes, cataract and cancer. However, the molecular mechanism underlying how metabolism and diet regulate aging remain unknown. We aim to address the molecular mechanism with a concept of "Optimal Nutrition" in which metabolism regulates cellular and tissue function in gender, circadian rhythm and tissue dependent manners. As an interdisciplinary longevity cluster, the study outcome will be developed into a novel anti-aging drug or intervention.
Project Member
About Project Members, ResearchersNote: "◎" indicates the program chairperson.
| Name | Affiliation | Position | Field of Specialization / Research Interests |
|---|---|---|---|
| ◎TSUBOTA Kazuo | School of Medicine | Professor | ophthalmology, immunology, aging, optogenetics |
| OKANO Hideyuki | School of Medicine | Professor | Neuroscience, Neurochemistry, Neuropharmacology, Molecular Biology, Developmental Biology |
| MIMURA Masaru | School of Medicine | Professor | Neuropsychology and Geriatric Psychiatry |
| ITOH Hiroshi | School of Medicine | Professor | Kidney internal medicine, Metabolomics, Endocrinology |
| WATANABE Mitsuhiro | Graduate School of Media and Governance | Professor | Health Science, Anti-aging, Metabolic Disease, Naturopathic Medicine, Preventive Medicine |
| FUKUDA Shinji | Graduate School of Media and Governance | Project Professor | Intestinal Ecosystem Regulation, Integrated Omics Science |
| ARITA Makoto | Faculty of Pharmacy | Professor | Molecular biology, Functional biochemistry, Biological pharmacy, General medical chemistry |
| FURUKAWA Yoshiaki | Faculty of Science and Technology | Associate Professor | Functional biochemistry |
| YASUI Masato | School of Medicine / Keio University Global Research Institute (KGRI) | Professor / Director | Water Biology and Medicine: understanding of in vivo water dynamics and the roles of aquaporins, Pharmacology |
| ARAI Yasumichi | School of Medicine | Assistant Professor | Geriatrics and gerontology, epidemiology of healthy aging and longevity |
| SIPP Douglas | School of Medicine | Project Professor | |
| NAKAHARA Jin | School of Medicine / Keio University Global Research Institute (KGRI) | Professor / Deputy-Director | Neurology, Neurotherapeutics, Neuroimmunology |
| CHAI Muh Chyi | Keio University Global Research Institute (KGRI) | Project Assistant Professor | General Neuroscience, Nerve Chemistry, Nerve Pharmacology, Molecular Biology, Developmental Biology |
| DEGUIA Roldan(2019/6/1-) | Keio University Global Research Institute (KGRI) | Project Assistant Professor |
