KGRI Lecture Series: (Nov.14, 2018) "Volumetric imaging of whole-tumors reveals cancer malignancy"


The Keio University Global Research Institute (KGRI) aims to promote international research and educational exchange and invites those working in the forefront of research and education in Japan and overseas to give lectures.

On this occasion, Prof. Per Uhlén from Karolinska Institute will give a lecture titled "Volumetric imaging of whole-tumorsreveals cancer malignancy. "

Date & time: Wednesday, November 14, 15:00-16:00
Venue: Center for Integrated Medical Research 1F Lounge, Shinanomachi Campus, Keio University
Co-Host: Department of Pharmacology School of Medicine, Keio University Global Research Institute's Longeivity Initiative
Language: English (No simultaneous interpretation provided)
Open to anyone. No admission fee, Pre-registration not required

Summary of Lecture:
Intratumoral heterogeneity is a critical factor when diagnosing and treating patients with cancer. Marked differences in the genetic and epigenetic backgrounds of cancer cells have been revealed by advances in genome sequencing, yet little is known about the phenotypic landscape of the intratumoral heterogeneity within solid tumors.
Our research group has developed new volumetric imaging methods, using three-dimensional light-sheet microscopy and the clearing technique, to characterize structural abnormalities of solid tumors from patients with cancer. Our methods can determine tumor stage and stratify patient prognosis from clinical samples with higher accuracy than current diagnostic methods, which will improve the design of more effective cancer therapies, resulting in positive effects on society.

Professor Per Uhlén Ph.D.:
Per Uhlén is Professor of Cell Signaling in the Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institute.

Karolinska Institute :
The Karolinska Institute (KI; Swedish: Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a medical university in Solna within the Stockholm urban area of Sweden. It is recognised as Sweden's best university and one of the largest, most prestigious medical universities in the world. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine.


Department of Pharmacology School of Medicine
Masato Yasui (E-mail: keio_pharm[at]ml.keio.jp)
(Please replace "[at]" with "@".)