イベント/長寿/開催案内

KGRI Lecture Series:(2019.10.18開催) " IP3 receptor/Ca2+ channel: from its discovery to a new paradigm in health and disease"

2019.10.18

慶應義塾大学グローバルリサーチインスティテュート(KGRI)では、国際的な研究・教育交流を図ることを目的として、最先端の研究・教育に携わる方を国内外よりお招きして講演会を開催しています。

今回は、上海科技大学より御子柴克彦教授をお招きして、" IP3 receptor/Ca2+ channel: from its discovery to a new paradigm in health and disease"と題して講演いただきます。


日 時:2019年10月18日(金)17:00-18:00 開場16:30
会 場:慶應義塾大学 信濃町キャンパス 3号館北棟ラウンジ
主 催:グローバルリサーチインスティテュート(KGRI)
言 語:英語(同時通訳なし)
その他:参加費無料,事前登録不要

講演概要:
Ca2+ plays an essential role in cell function. It conveys signals to the most important cell process but the detailed mechanism of signaling process is not clearly understood. We have discovered a key regulator of Ca2+ signaling, the IP3 receptor (IP3R) as a P400 protein greatly decreased in the cerebellum of Purkinje cell-degeneration mutant mice, and have subsequently cloned its cDNA.
We identified it is endoplasmic reticulum (ER) channel that convert GPCR-IP3 signals to Ca2+ signal at the ER to produce Ca2+ oscillation. We found that IP3R is essential for fertilization, dorso-ventral axis formation, neurite extension, cardiogenesis, exocrine secretion and behavior. We found IP3R interacts ER chaperons to protect from apoptosis caused by ER stress response. A newly discovered pseudo-IP3 which we named IRBIT that binds to IP3R and is involved in apoptosis regulation in association with anti-apoptotic proteins. We recently crystalized a large cytosolic domain (2217aa) of IP3R in the presence and absence of IP3 and solved the gating mechanism by biochemical and X-ray crystallographic analysis. We have identified a "leaflet" structure essential for allosteric channel gating, surrounded by functional molecules that may regulate IP3R activity to balance normal/abnormal state. I will discuss about a new paradigm in health and disease.

御子柴克彦教授のプロフィール:
Professor, SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University
Specially Appointed Professor, Faculty of Science, Toho University
Guest Professor (Global) of Keio University


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本件に関するお問い合わせ
医学部薬理学教室(e-mail: keio_pharm[at]ml.keio.jp)
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