KGRI Lecture Series:（2019.10.18開催） " IP3 receptor/Ca2+ channel: from its discovery to a new paradigm in health and disease"
2019.10.18慶應義塾大学グローバルリサーチインスティテュート(KGRI)では、国際的な研究・教育交流を図ることを目的として、最先端の研究・教育に携わる方を国内外よりお招きして講演会を開催しています。
今回は、上海科技大学より御子柴克彦教授をお招きして、" IP3 receptor/Ca2+ channel: from its discovery to a new paradigm in health and disease"と題して講演いただきます。
日 時：2019年10月18日（金）17:00－18:00 開場16:30
会 場：慶應義塾大学 信濃町キャンパス ３号館北棟ラウンジ
主 催：グローバルリサーチインスティテュート(KGRI)
言 語：英語（同時通訳なし）
その他：参加費無料，事前登録不要
講演概要：
Ca2+ plays an essential role in cell function. It conveys signals to the most important cell process but the detailed mechanism of signaling process is not clearly understood. We have discovered a key regulator of Ca2+ signaling, the IP3 receptor (IP3R) as a P400 protein greatly decreased in the cerebellum of Purkinje cell-degeneration mutant mice, and have subsequently cloned its cDNA.
We identified it is endoplasmic reticulum (ER) channel that convert GPCR-IP3 signals to Ca2+ signal at the ER to produce Ca2+ oscillation. We found that IP3R is essential for fertilization, dorso-ventral axis formation, neurite extension, cardiogenesis, exocrine secretion and behavior. We found IP3R interacts ER chaperons to protect from apoptosis caused by ER stress response. A newly discovered pseudo-IP3 which we named IRBIT that binds to IP3R and is involved in apoptosis regulation in association with anti-apoptotic proteins. We recently crystalized a large cytosolic domain (2217aa) of IP3R in the presence and absence of IP3 and solved the gating mechanism by biochemical and X-ray crystallographic analysis. We have identified a "leaflet" structure essential for allosteric channel gating, surrounded by functional molecules that may regulate IP3R activity to balance normal/abnormal state. I will discuss about a new paradigm in health and disease.
御子柴克彦教授のプロフィール：
Professor, SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University
Specially Appointed Professor, Faculty of Science, Toho University
Guest Professor (Global) of Keio University
ポスター
本件に関するお問い合わせ
医学部薬理学教室（e-mail: keio_pharm[at]ml.keio.jp）
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