KGRI Lecture Series: (Sep.21, 2018) "The Emergence of Tau in our Understanding of Frontotemporal Dementia."2018.09.11
The Keio University Global Research Institute (KGRI) aims to promote international research and educational exchange and invites those working in the forefront of research and education in Japan and overseas to give lectures.
On this occasion, Prof. Bernardino Ghetti from Distinguished Professor, Indiana University will give a lecture titled "The Emergence of Tau in our Understanding of Frontotemporal Dementia. "
Date & time: Friday, September 21, 19:00-20:00 (Open 18:55)
Venue: Building 3 (North Wing) 1F Lounge, Shinanomachi Campus, Keio University
Host: Keio University Global Research Institute's Longeivity Initiative
Language: English (No simultaneous interpretation provided)
Other: Open to anyone. No admission fee, Pre-registration not required
Summary of Lecture:
"The Emergence of Tau in our Understanding of Frontotemporal Dementia."
Intracellular filamentous Tau inclusions accumulate in several human sporadic and inherited neurodegenerative diseases. Neurons and glia may be involved, in different combinations, according to disease entity.
Six Tau isoforms are expressed in adult human brain. They are produced by alternative mRNA splicing of transcripts from MAPT, the Tau gene, and differ by the presence or absence of inserts of 29 or 58 amino acids in the amino-terminal half, and the inclusion or not, of the 31 amino-acid repeat encoded by exon 10 in the carboxy-terminal half. Inclusion of exon 10 results in the production of three Tau isoforms with four repeats each (4R), and its exclusion in three isoforms with three repeats each (3R).
Tau pathology occurs as a primary event in Frontotemporal Dementia (FTD). In dominantly inherited FTD, the filamentous Tau may differ according to MAPT mutations and may be composed by any of the following: 3R, 4R, or 3R&4R isoforms. In FTD, the Tau anatomical footprint varies along with the 3R, 4R, or 3R&4R signatures. Both gray and white matter may display Tau deposits in the presence of 3R or 4R signatures. The white matter pathology is severe in association with the 4R Tau signature, but not in association with the 3R&4R signature.
University of Pisa, Italy MD 02/1967 Medicine
University of Pisa, Italy Specialization 06/1969 Mental/Nervous Disorders
University of Naples, Italy Postdoctoral 04/1970 Neuropathology
Albert Einstein College of Medicine, NY Postdoctoral 06/1973 Path/Neuropathology
Albert Einstein College of Medicine, NY Residency 06/1976 Path/Neuropathology
Cincinnati Psychoanalytic Institute, OH Post-graduate 06/2014 Adult Psychoanalysis
1977-1978 Assistant Professor of Psychiatry, Indiana University, Indianapolis, IN
1978-1983 Associate Professor of Pathology and Psychiatry, Indiana University, Indianapolis, IN
1980-date Graduate Faculty, Indiana University, Indianapolis, IN
1983-date Professor of Pathology and Psychiatry, Indiana University, Indianapolis, IN
1983-2000 Assoc. Director Graduate Program in Medical Neurobiology, Indiana University, Indianapolis, IN
1991-date Professor of Medical and Molecular Genetics, Indiana University, Indianapolis, IN
1997-date Professor of Neurology, Indiana University, Indianapolis, IN
1997-date Distinguished Professor, Indiana University, Indianapolis, IN
2007-date Chancellor's Professor, Indiana University-Purdue University, Indianapolis, IN
Department of Neuropsychology and Geriatric Psychiatry, School of Medicine
Yukiko Miyasaka (E-mail: miyasakai[at]a5.keio.jp)
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